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The GNAO1 gene encodes an alpha subunit of the heterotrimeric guanine nucleotide-binding proteins (G proteins), a large family of signal-transducing. Master switch: Metabotropic glutamate receptors are promising targets for the treatment of several CNS disorders. Antonicek, J Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. , Bertrand G. , Blenis J. Experiments were carried out under the committee's guidelines. View in L.